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A 47-Year-Old Man with Gastroesophageal Reflux Disease Comes to the Physician

Question 748

Multiple Choice

A 47-year-old man with gastroesophageal reflux disease comes to the physician because of severe burning chest pain and belching after meals. The discomfort has been less responsive than usual to over-the-counter antacids.   He has no other chronic medical conditions. He has limited his caffeine intake and has been avoiding food close to bedtime. BMI is 34 kg/m2.  Vital signs are within normal limits.  Physical examination reveals no abnormalities.  The recent worsening of this patient's symptoms is most likely related to which of the following?


A) Columnar metaplasia
B) Herpes simplex infection
C) Malignancy
D) Stricture
E) Ulceration

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