A 5-year-old girl is brought to the physician because of generalized fatigue and dark urine for 3 days. Four weeks ago, she was treated with topical mupirocin for a skin infection. Medical history is otherwise unremarkable and she takes no routine medications. Blood pressure is 140/90 mm Hg. Urinalysis reveals hematuria, mild proteinuria, and occasional red blood cell casts. Which of the following changes would most likely be present on this patient's renal biopsy?

Question

A 5-year-old girl is brought to the physician because of generalized fatigue and dark urine for 3 days. Four weeks ago, she was treated with topical mupirocin for a skin infection. Medical history is otherwise unremarkable and she takes no routine medications.   Blood pressure is 140/90 mm Hg.  Urinalysis reveals hematuria, mild proteinuria, and occasional red blood cell casts.  Which of the following changes would most likely be present on this patient's renal biopsy?

Quizplus · Accepted Answer

Eductional Objective: Poststreptococcal glomerulonephritis is an immune complex-deposition disease that occurs 2-4 weeks after exposure to group A beta-hemolytic Streptococcus species (eg, pharyngitis, skin infection).  Light microscopy shows enlarged, hypercellular glomeruli.  Immunofluorescence demonstrates a "lumpy-bumpy" granular deposits of IgG and C3 on the glomerular basement membrane, and subepithelial, electron-dense deposits are seen on electron microscopy.

A 5-Year-Old Girl Is Brought to the Physician Because of Generalized