A 34-year-old nulliparous woman comes to the physician because of a 5-month history of heavy menstrual bleeding. She has a monthly cycles lasting 7-10 days and normal blood flow with the passage of large clots. . Pelvic examination shows an asymmetrically enlarged, fibroid uterus, and she is found to have significant anemia due to blood loss. A urine pregnancy test is negative. The patient is prescribed continuous leuprolide therapy. After several weeks, which of the following sustained hormonal changes are expected to have occurred as a result of the treatment?

Question

A 34-year-old nulliparous woman comes to the physician because of a 5-month history of heavy menstrual bleeding. She has a monthly cycles lasting 7-10 days and normal blood flow with the passage of large clots.  . Pelvic examination shows an asymmetrically enlarged, fibroid uterus, and she is found to have significant anemia due to blood loss. A urine pregnancy test is negative. The patient is prescribed continuous leuprolide therapy.  After several weeks, which of the following sustained hormonal changes are expected to have occurred as a result of the treatment?

Quizplus · Accepted Answer

Eductional Objective: Leuprolide is a GnRH agonist used to treat symptomatic uterine fibroids (eg, heavy menses, anemia).  When administered in a continuous fashion, leuprolide inhibits the release of endogenous hypothalamic GnRH and downregulates pituitary GnRH receptors, thereby decreasing GnRH, FSH, and estrogen levels (ie, hypogonadotropic hypogonadism).

A 34-Year-Old Nulliparous Woman Comes to the Physician Because of a 5-Month