A 24-Year-Old Woman Comes to the Physician to Establish Care

A 24-year-old woman comes to the physician to establish care after moving to a new city. She reports that she has a history of epilepsy. She takes valproate regularly. She planning to conceive next month but her physician inform her about the teratogenic of the medication. The patient takes no other medications and does not use tobacco, alcohol, or illicit drugs. Blood pressure is 120/80 mm Hg. Physical examination is normal. If the patient conceives now, her fetus is at increased risk for which of the following anomalies?

A) Epiphyseal stippling
B) Hypothyroidism
C) Micrognathia
D) Myelomeningocele
E) Nasal hypoplasia
F) Renal dysgenesis
G) Tricuspid valve malformation