An 8-year-old boy is brought by his mother due to concerned to his weight. The patient weight is on 5th percentile for his age. He has no medical conditions or family history of any inheritied diseases. On examination, the patient is hyperactive with sweating hand, impulsive, inattentive, and restless. His grade has declined recently. The thyroid gland is diffusely enlarged to palpation without tenderness or bruit. Neurologic examination reveals no focal findings. Results of thyroid function tests are : elevation of TSH, T4 and Total T3. Which of the following is the most likely etiology of this patient's thyroid function test abnormalities?

Question

An 8-year-old boy is brought by his mother due to concerned to his weight. The patient weight is on 5th percentile for his age. He has no medical conditions or family history of any inheritied diseases. On examination, the patient is hyperactive with sweating hand, impulsive, inattentive, and restless. His grade has declined recently. The thyroid gland is diffusely enlarged to palpation without tenderness or bruit.  Neurologic examination reveals no focal findings.  Results of thyroid function tests are : elevation of TSH, T4 and Total T3. Which of the following is the most likely etiology of this patient's thyroid function test abnormalities?

Quizplus · Accepted Answer

Eductional Objective: A defect in the thyroid hormone receptors result in a thyroid hormone resistance at the preipheral tissues. Levels of thyroxine, triiodothyronine, and TSH are increased. Patients classically have goiter and frequently develop attention deficit hyperactivity disorder.

An 8-Year-Old Boy Is Brought by His Mother Due to Concerned