A physiologist is conducting an experiment to study potassium channels mutation expressed in pancreatic beta cells. The mutated channels have a higher sensitivity to the substance that normally modulates their activity, causing increased beta cell secretory activity. Which of the following substances normally binds to and regulates the ion channels that are responsible for this patient's hypoglycemia?

Question

A physiologist is conducting an experiment to study potassium channels mutation expressed in pancreatic beta cells. The mutated channels have a higher sensitivity to the substance that normally modulates their activity, causing increased beta cell secretory activity.  Which of the following substances normally binds to and regulates the ion channels that are responsible for this patient's hypoglycemia?

Quizplus · Accepted Answer

Eductional Objective: Oxidative metabolism of glucose in pancreatic beta cells generates ATP.  ATP-induced closure of the ATP-sensitive potassium channels leads to membrane depolarization and subsequent insulin release.

A Physiologist Is Conducting an Experiment to Study Potassium Channels