Scientists studying the kidney's response to severe renal artery stenosis that reduces blood flow to the kidney by about 70%. they perform a right nephrectomy and examine the glomeruli and tubules microscopically. Which of the following cell types would be most likely to undergo hyperplasia as a result of the clip placement?

Question

Scientists studying the kidney's response to severe renal artery stenosis that reduces blood flow to the kidney by about 70%.  they perform a right nephrectomy and examine the glomeruli and tubules microscopically.  Which of the following cell types would be most likely to undergo hyperplasia as a result of the clip placement?

Quizplus · Accepted Answer

Eductional Objective: Renal artery stenosis causing significant renal hypoperfusion will result in a decreased glomerular filtration rate and activation of the renin-angiotensin-aldosterone system.  This leads to increased renin release by modified smooth muscle (juxtaglomerular) cells in the walls of afferent glomerular arterioles.  Chronic renal hypoperfusion can cause hyperplasia of the juxtaglomerular apparatus.

Scientists Studying the Kidney's Response to Severe Renal Artery Stenosis