Researchers are studying treatment of osteoporotic fractures. Subjects with pelvic fractures due to osteoporosis are divided into 2 groups. The control group receives physical therapy along with calcium and vitamin D supplementation. The experimental group receives a parathyroid hormone analogue in addition to the standard therapy. It is found that the subjects who receive hormonal treatment have a shorter time to fracture healing and improved functional outcome. The benefits of the investigational medication are attributed to increased osteoblastic activity. An elevated level of which of the following markers is most likely to reflect the medication effect in these subjects?

Question

Researchers are studying treatment of osteoporotic fractures.  Subjects with pelvic fractures due to osteoporosis are divided into 2 groups.  The control group receives physical therapy along with calcium and vitamin D supplementation.  The experimental group receives a parathyroid hormone analogue in addition to the standard therapy.  It is found that the subjects who receive hormonal treatment have a shorter time to fracture healing and improved functional outcome.  The benefits of the investigational medication are attributed to increased osteoblastic activity.  An elevated level of which of the following markers is most likely to reflect the medication effect in these subjects?

Quizplus · Accepted Answer

Eductional Objective: Bone-specific alkaline phosphatase levels correlate with osteoblast activity.  Other markers of osteoblast activity include N-terminal propeptide of type 1 procollagen, which is released during post-translation cleavage of type 1 procollagen

Researchers Are Studying Treatment of Osteoporotic Fractures