An 80-year-old male comes to the office because he feels constipation and fatigue for 1 month. He smokes 15 cigarettes daily. He has chronic hypertension and diabetes type II adhere to his medication. He has no family history of cancer. A colonoscopy is done and revealed a colon cancer, CT shows no metastatic. al. A chemotherapy regimen containing a medication that is primarily metabolized by the liver is chosen for therapy. Because of the patient's age, the physician is considering adjusting the dose to prevent adverse effects. Which of the following parameters is likely to be the most similar between this patient and a healthy 40-year-old individual?

Question

Quizplus · Accepted Answer

Eductional Objective: A number of changes occur in the liver with aging that can affect drug metabolism.  Typical changes include decreased liver mass and blood flow, decreased cytochrome P-450 expression and concentration, and reduced hepatic regeneration after injury.  However, hepatic aminotransferase levels are unchanged.

An 80-Year-Old Male Comes to the Office Because He Feels