A 35-year-old woman is brought to your clinic due to chronic and persistent diarrhea for 5 months. She has 10-12 episodes a day of tea-colored, odorless, watery stools. She tried to avoid dairy products but the symptoms still persist. The patient has uncomfortable abdominal palpation otherwise is normal. Temperature is 37.1 C . Sampling of her gastric contents shows a total lack of gastric acid secretion. Somatostatin treatment promptly relieves the symptoms. An excess of which of the following hormones is most likely responsible for this patient's symptoms?

Question

Quizplus · Accepted Answer

Eductional Objective: VIPomas are neuroendocrine tumor that secretes VIP. It's associated with MEN1 syndrome. Excess VIP increase relaxation of gastric and intestinal smooth muscles and cAMP activity (similar to cholera toxin) which leads to secretory diarrhea , inhibition of gastric acid production, hypokalemia, hypercalcemia and hyperglycemia

A 35-Year-Old Woman Is Brought to Your Clinic Due to Chronic