A 70-year-old male with a chronic kidney disease due to diabetic nephropathy comes for follow up. The patient states that he cannot do his daily routine due to progressive weakness and fatigue for several months. He has hypertension and is compliant with his medication otherwise normal. His laboratory tests revealed that he has anemia. He started on an oral supplement with recombinant glycoprotein hormone . and repeat laboratory testing several weeks later shows an improvement in hemoglobin level. The effects of the hormone prescribed for this patient are most likely mediated by which of the following pathways?

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Eductional Objective: Chronic kidney disease is commonly associated with normocytic anemia due to reduced production of erythropoietin by the kidneys.  Erythropoietin signal transduction is primarily mediated by the Janus kinase 2/signal transducers and activators of transcription (JAK2/STAT) pathway, which promotes erythrocyte precursor survival.

A 70-Year-Old Male with a Chronic Kidney Disease Due to Diabetic