A 35-year-old woman comes to the office for follow up. She has a history of celiac disease and she was diagnosed with iron deficiency anemia , she has started on iron supplements. The woman is concerned about side effects of the supplement. She is reassured that iron homeostasis is closely regulated; as the body's iron stores increase, a hormone is released and functions in reducing the amount of dietary iron absorbed from the intestines. Which of the following cells is most likely responsible for secreting this hormone?

Question

Quizplus · Accepted Answer

Eductional Objective: Hepcidin is one of the iron hemostasis proteins in liver and inflammatory markers. During high iron levels leads to increase the synthesis of hepcidin. In contrast hypoxia and increased erythropoiesis act to lower hepcidin levels.
Low hepcidin levels increase intestinal iron absorption and stimulate iron release by macrophages

A 35-Year-Old Woman Comes to the Office for Follow Up