Which chromosomal abnormality is commonly associated with chronic myelogenous leukemia?
A) Nondisjunction of chromosome 21
B) Defects in the TP53 tumor suppressor gene
C) Inversion at chromosome 22
D) Translocation of chromosome 9 and 22 leading to a fusion protein known as BCR-ABL

Question

Quizplus · Accepted Answer

Chronic myelogenous leukemia (CML) is commonly associated with the Philadelphia chromosome, which results from a translocation between chromosome 9 and 22, creating the BCR-ABL fusion protein.

Which Chromosomal Abnormality Is Commonly Associated with Chronic Myelogenous Leukemia