A key pathologic change in the articular cartilage in osteoarthritis is:
A) the loss of proteoglycans, which is a substance that makes up cartilage.
B) increased osteoclastic activity leading to cartilage destruction.
C) autoimmune-mediated destruction.
D) chronic synovial membrane inflammation.

Question

Quizplus · Accepted Answer

In osteoarthritis, the articular cartilage undergoes degeneration primarily due to the loss of proteoglycans, which are essential for maintaining cartilage structure and function.

A Key Pathologic Change in the Articular Cartilage in Osteoarthritis