In Which Patients Would the Manifestation of a Headache Be

In which patients would the manifestation of a headache be a sign of a serious underlying disorder?

A) A 55-year-old man with new onset of headaches that are worse at night and reported mood swings according to his family
B) A 30-year-old woman with a unilateral throbbing headache with photophobia and nausea
C) A 60-year-old man with his head feeling full and throbbing and muscle aching around his neck and shoulders
D) A 40-year-old woman who experiences food cravings, gets irritable, and then develops a pulsatile-like headache on the right side of her head