Which of the Following Statements Are True About Conjugation Polymers

Which of the following statements are true about conjugation polymers and ligands to nanocarrier's surface?

A) Conjugation of proteins or polymers can proceed covalently and non-covalently
B) Reactive thiol-groups are preferred in protein bioconjugation because they are less ubiquitous than carboxylic ones
C) Activation of carboxylic groups can drive protein-to protein crosslinking
D) Protein-to protein crosslinking often increases the binding activity of proteins attached to the nanocarrier.
E) Proteins and polymers capped with lipidic moieties can be easily adsorbed in the hydrophobic surface of nanoparticles or in liposome membranes