Unlike the first generation antihistamines,the second-generation antihistamines (e.g. Loratidine (Claritin)),are more ____________ and therefore lack the ability to appreciably cross the BBB thus failing to produce adverse effects in the CNS.

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Second-generation antihistamines are more hydrophilic, which means they are less able to cross the blood-brain barrier (BBB) and therefore less likely to produce adverse effects in the CNS.

Unlike the First Generation Antihistamines,the Second-Generation Antihistamines (E