There Is an Increased Safety Concern of Magnetofection in the Following

There is an increased safety concern of magnetofection in the following case:

A) When the brain is the intended target tissue.
B) When the size of DNA plasmid is larger than 5 kb.
C) When multi-dosing regimen is required for disease management.
D) When the target tissue is internal rather than superficial tissue.
E) None of the above.