The major hyposecretory disorder of the adrenal cortex is known as Addison's disease.

Name: The major hyposecretory disorder of the adrenal cortex is known as Addison's disease.
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Addison's disease is a disorder that occurs when the adrenal glands located at the top of the kidneys do not produce enough of their hormones, specifically cortisol and, in some cases, aldosterone. This condition is indeed a major hyposecretory disorder of the adrenal cortex.

The Major Hyposecretory Disorder of the Adrenal Cortex Is Known