Chloride Channels Are Disrupted in Patients with Cystic Fibrosis

Chloride channels are disrupted in patients with Cystic Fibrosis. What implications does this have on ion transport, water, and airway clearance?

A) Defective chloride transport and enhanced sodium absorption lead to a net increase in water absorption, thinned airway surface liquids, and decreased ciliary clearance.
B) Defective chloride transport and enhanced sodium absorption lead to a net decrease in water absorption, thinned airway surface liquids, and decreased ciliary clearance.
C) Defective sodium transport and enhanced chloride absorption lead to a net increase in water absorption, thinned airway surface liquids, and decreased ciliary clearance.
D) Defective chloride transport and enhanced calcium absorption lead to a net decrease in water absorption, thinned airway surface liquids, and decreased ciliary clearance.