In addition to the classic "salt and pepper" appearance on x-ray of the skull, what other lab value is needed to diagnose Paget's Disease of the Bone?

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Quizplus · Accepted Answer

"The diagnosis of PDB is made by finding an elevated serum alkaline phosphatase and characteristic radiographic findings. The classic "salt and pepper" appearance on plain radiographs is consistent with the osteoblast (salt) and osteoclast (pepper) dysregulation of bone." (Genetics, Chapter 23- Rheumatologic Diseases, page 5, paragraph 1)

In Addition to the Classic "Salt and Pepper" Appearance on X-Ray