A client is found to have an increased level of the VKORC1 enzyme. How should you expect the client's dose of warfarin to be affected?

Question

Quizplus · Accepted Answer

Warfarin acts by inhibiting vitamin K epoxide reductase complex subunit
1 (VKORC1). If the client has a higher level of the VKORC1 enzyme, the amount of warfarin dose should be increased to overcome the resistance to vitamin K. If the warfarin dose is unchanged or lower, it will take longer for effective anticoagulation to occur. There is no need to identify a different anticoagulant; the dose just needs to be adjusted upward.

A Client Is Found to Have an Increased Level of the VKORC1