Which of the following pathophysiologic events contributes to renal failure associated with tumor lysis syndrome?
A) Hypocalcemia
B) Elevated white blood cell count
C) Metabolic acidosis
D) Crystallization of uric acid in the renal tubules

Question

Quizplus · Accepted Answer

When therapy is initiated, tumor cell destruction releases nucleic acids, which are metabolized into uric acid.Metabolic acidosis ensues, resulting in crystallization of the uric acid in the distal tubules of the kidneys and leading to obstruction of urine flow.Glomerular filtration rates drop as the kidneys are unable to clear the increasing amounts of uric acid.Consequently, acute kidney injury eventually occurs.

Which of the Following Pathophysiologic Events Contributes to Renal Failure