Arguments Against the Use of Selective Estrogen Receptor Modulators Such

Arguments against the use of selective estrogen receptor modulators such as Tamoxifen for the chemoprevention of breast cancer include:

A) the absence of statistically significant reductions in the incidence of breast cancer among women receiving the drug in some randomized clinical trials.
B) lack of compliance in the trials.
C) a significant increase in the death rate among women receiving the drug in one trial.
D) heterogeneity of study design in all trials.
E) Only a and c are correct.