Which One of the Following Is Not a Principle of Hormonal

Which one of the following is not a principle of hormonal control?

A) Hormones may interact with each other synergistically, permissively, or antagonistically.
B) Many endocrine controls operate in tightly coordinated ways with neural controls.
C) Many molecules that function as hormones in one context function as different types of chemical signals in different contexts.
D) A hormone in one species typically affects only one physiological system, although it may affect a different physiological system in a different species.