Which Statement Best Reflects the Evolutionary History of the Ligand-Gated

Which statement best reflects the evolutionary history of the ligand-gated channel?

A) The sequence homology of the ligand-gated receptors is similar to that of voltage-gated receptors.
B) Ligand-gated channels have had a minimum of three independent appearances in evolutionary history.
C) Ligand-gated channels in the neuromuscular junction are evolutionarily distinct from ligand-gated channels in the brain.
D) Most kinds of ligand-gated channels appear to have evolved from a common ancestor.