Summarize and explain the aromatization hypothesis of sexual differentiation in the brain. Be sure to include the role of specific gonadal secretions, the blood-brain-barrier, brain sites where aromatization is believed to occur, relevant steroid receptor(s) locations relative to the cell membrane, aromatase basic function and describe the intracellular activities of this process thereafter. When is the sensitive phase for brain differentiation in humans? In rats? Give clear descriptions of this schema for typical male and female behavioral outcomes.
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