When the production of acetyl-CoA exceeds the body's capacity to oxidize it, acetoacetate, $\beta$-hyroxybutyrate and acetone accumulate. When generated in large amounts, these substances can exceed the blood's buffering capacity. As the blood pH falls, the ability of red blood cells to carry oxygen is affected. Subsequently, the brain can be starved of oxygen and a fatal coma can result. Explain how severe dieting can produce this condition.

Question

Quizplus · Accepted Answer

The Answer of When the production of acetyl-CoA exceeds the body's capacity to oxidize it, acetoacetate, $\beta$-hyroxybutyrate and acetone accumulate. When generated in large amounts, these substances can exceed the blood's buffering capacity. As the blood pH falls, the ability of red blood cells to carry oxygen is affected. Subsequently, the brain can be starved of oxygen and a fatal coma can result. Explain how severe dieting can produce this condition.

When the Production of Acetyl-CoA Exceeds the Body's Capacity to Oxidize