Which of the Following Best Describes a Phase II Trial

Which of the following best describes a phase II trial?

A) Relatively small randomized, blinded trial that tests tolerability and different intensity or dose of the intervention on surrogate or clinical outcomes
B) Studies involving animals or cell cultures
C) Relatively large randomized, blinded trial used to evaluate the efficacy of an intervention
D) An unblinded and uncontrolled study involving a few volunteers to test the safety of an intervention
E) Large studies (may or may not be a randomized trial) conducted after the therapy has been approved by the FDA to assess the rate of serious side effects and explore further therapeutic uses