Without Drugs, Do Humans Have Any Inborn Defenses Against Malaria

Without drugs, do humans have any inborn defenses against malaria?

A) Yes. The immune systems of some people automatically recognize the pathogens involved and they remain uninfected.
B) No. That's why it's the most deadly disease in human history.
C) Yes. Certain genetic mutations like the one that causes sickle-shaped red blood cells offer some resistance to it.
D) No. That's why the organisms that cause it are able to mutate so easily.
E) Yes. Certain genetic mutations make a small percentage of people completely resistant to the infection.