Why Would Natural Selection Tend to Select Against Hybrids

Why would natural selection tend to select against hybrids?

A) They aren't really natural so they can't be well adapted.
B) Natural selection only works on species.
C) Hybrids can't evolve since they have different parents who are better adapted to their own habitats.
D) Hybrids tend not to be as well adapted as their parents because they haven't been in their environment for as long, so they're less fit.
E) Natural selection always tends to favor older, established species over new ones.