A Change in DNA Resulting in an Incorrect Protein Is

A change in DNA resulting in an incorrect protein is the problem in sickle cell disease. Is this normally the problem in genetic diseases?

A) No. Most genetic diseases result from errors in cell division.
B) No. In other genetic diseases, the proteins are all correctly made, but then they damage the DNA.
C) It's not clear what the problem is in most genetic diseases.
D) Yes, abnormal proteins created by abnormal DNA is the problem in all genetic diseases.
E) Yes, the DNA may be "correct" but can produce abnormal proteins which cause disease.