Which of These Is One of the Ways the Landscape

Which of these is one of the ways the landscape of the Great Lakes region was changed by violence and disease?

A) captivity and disbursement of the Huron
B) rise of the Huron, who became the most powerful Indian tribe in the Great Lakes region
C) decline of the Iroquois, who were forced to flee the area and relocate further west
D) merging of the Iroquois and Huron into one formidable confederation