The FDA Discourages Use of Depo-Provera for More Than About

The FDA discourages use of Depo-Provera for more than about two years because

A) long term use has been shown to increase risk of ovarian cancer.
B) use greater than three years is associated with permanent reduced fertility.
C) loss of bone density that occurs while using the contraceptive may not recover completely.
D) long term use is associated with subsequent birth defects.
E) health plans do not fund this contraceptive after two consecutive years of use.