All of the Following Are Limitations of Randomized Controlled Trials

All of the following are limitations of randomized controlled trials for the investigation of safety, except:

A) sample size limits the ability of randomized controlled trials to observe rare, but serious, side effects.
B) short duration of most randomized controlled trials limits the ability to observe long-term side effects.
C) serious side effects are often overlooked due to infrequent observation.
D) patients in randomized controlled trials often have less-complex clinical presentations than those in practice.