_______ Is/are Required for Any Evolutionary Response, While the _______

_______ is/are required for any evolutionary response, while the _______ determine(s) the rate at which genetic variation is lost by chance.

A) Mutations; phenotypes
B) Genetic variation; isolation of a population
C) Genetic drift; rate of mutation
D) Isolation of a population; size of a population
E) Genetic variation; size of a population