The major defenses of excuse are infancy of age, insanity, mistake, intoxication and duress.

Name: The major defenses of excuse are infancy of age, insanity, mistake, intoxication and duress.
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These are recognized as major defenses of excuse in criminal law, where the defendant argues that they should not be held fully responsible for their actions due to their mental state or circumstances at the time of the offense.

The Major Defenses of Excuse Are Infancy of Age, Insanity