Why Would Inhibition of Nogo Likely Not Result in Full

Why would inhibition of Nogo likely not result in full recovery of locomotor function following spinal cord injury?

A) The complexity of even a simple axotomy is too high that recovery is dependent on a plethora of factors, as well as on the timing of when these factors are active.
B) How Nogo is inhibited, whether by a drug or an antibody, is critical whether full recovery occurs.
C) Nogo is not expressed in amounts high enough that would impact full recovery.
D) Nogo receptors are not expressed in high enough amounts that would impact full recovery.
E) Nogo binds to its receptor with relatively low affinity.