Autonomic ganglion neurons switch from phasic-firing to tonic-firing when

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M-channels, which are a type of potassium channel, contribute to the regulation of neuronal excitability. When M-channels are closed, neurons are less able to repolarize after an action potential, leading to a state where they can fire action potentials more continuously, or tonically, rather than in bursts, or phasically. This is because the closure of M-channels decreases the efflux of K+, leading to a depolarized state that favors tonic firing.

Autonomic Ganglion Neurons Switch from Phasic-Firing to Tonic-Firing When