The primary reason women have given for discontinuation of progestin only contraceptives (e.g. ,Depo-Provera)is:

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Studies have shown that weight gain is the most common reason for discontinuation of progestin-only contraceptives such as Depo-Provera. Other possible side effects include irregular bleeding, mood changes, and decreased libido, but these are less commonly reported as reasons for discontinuation.

The Primary Reason Women Have Given for Discontinuation of Progestin