Which of the following tests would be effective at determining if a transmitter action was mediated by a G protein-coupled receptor?
A) Adding extra GTP to the cell cytoplasm to activate G protein-coupled receptors.
B) The addition of cholera toxin to inhibit G protein-coupled receptors.
C) The addition of GDP-β-s enhances and greatly prolongs agonist-induced activation of G protein-mediated responses.
D) The addition of GTP-γ-s enhances and greatly prolongs agonist-induced activation of G protein-mediated responses.
E) The addition of pertussis toxin to activate G protein-coupled receptors.
Correct Answer:
Verified
Q4: Each particular metabotropic receptor (e.g., a metabotropic
Q5: When different transmitters or hormones act through
Q6: The G proteins that coupled to metabotropic
Q7: For G protein-coupled metabotropic receptors, GTP binds
Q8: How is G protein-mediated signaling terminated?
A) Desensitization
Q10: G proteins are activated when GDP is
A)
Q11: The particular neurotransmitter present at a synapse
A)
Q12: Non-hydrolysable GTP analog is an analog of
Q13: What would happen to G protein-coupled metabotropic
Q14: What would happen to metabotropic signaling in
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