An Example of Convergent Signaling Mediated by Indirectly Coupled Receptors

An example of convergent signaling mediated by indirectly coupled receptors is…

A) Phospholipase C cleaving PIP₂ to generate both DAG and IP₃.
B) GABA and Norepinephrine receptors both using G proteins to mediate signaling.
C) Muscarinic receptors in guinea pig sympathetic neurons that can affect five different potassium currents.
D) GABA receptor activation of both G_i and G_o proteins that leads to the opening of potassium channels and the closing of calcium channels.
E) A rat superior cervical sympathetic neuron modulated by multiple transmitters acting through many different G protein-coupled pathways that influence several types of ion channels.