What happens to the reversal potential for IPSPs when chloride is injected into an adult neuron to increase the cytoplasmic concentration of chloride?

Question

Quizplus · Accepted Answer

The reversal potential for inhibitory postsynaptic potentials (IPSPs), which are primarily mediated by chloride ions (Cl-), becomes more positive when the cytoplasmic concentration of chloride is increased. This is because the increased internal chloride concentration reduces the electrochemical gradient for chloride ions to move into the cell, thus requiring a more positive membrane potential to balance the inward and outward movements of chloride ions, which in turn shifts the reversal potential in a more positive direction.

What Happens to the Reversal Potential for IPSPs When Chloride