How can you test the hypothesis that demyelination disrupts the confined expression of voltage-gated sodium channels in the node of Ranvier?
A) By analyzing the effect of diphtheria toxin on action potential repolarization
B) By changing the ionic composition of the extracellular solution where the isolated nerve fiber is stored
C) By severing nerve fibers
D) By using pharmacological agents that block KCNQ2-containing M-channels
E) By comparing the sodium channel distribution along myelinated and demyelinated fibers treated with diphtheria toxin
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