Hydrophobicity of Amino Acid Residues Informs Which Property of NAChRs

Hydrophobicity of amino acid residues informs which property of nAChRs?

A) Their primary structure, i.e., amino acid sequence
B) Secondary and tertiary structure: membrane insertion of alpha helices
C) Secondary and tertiary structure: configuration of intracellular loops
D) Secondary and tertiary structure: ligand-binding site(s)
E) Quaternary structure: arrangement of subunits