Why were electric eels used to discover nAChRs and voltage-activated sodium channels but not voltage-activated potassium channels?
A) nAChRs and voltage-activated sodium channels in eels are similar in structure and function to vertebrate channels so they make a good model to understand channels across phylogeny.
B) Electric eels provide an abundance of channels for biochemical purification prior to sequencing and cloning, but voltage-activated potassium channels were cloned using a different strategy.
C) A-type voltage-activated potassium channels are not expressed in electric eels, whereas those A-type channels are expressed in invertebrate Drosophila (fruit flies) .
D) Electric eels are aquatic organisms and thus sensitive to toxins like α-bungarotoxin, TTX, and STX, which assist in biochemical purification.
E) Shaker-type mutants were a fortuitous discovery that facilitated biochemical purification of voltage-activated potassium channels thus obviating the need an eel-like model system with abundant channels.
Correct Answer:
Verified
Q16: Modification of the primary structure of a
Q17: What technique allowed scientists to view nAChRs
Q18: Maximal channel current in nAChRs depends on
A)
Q19: With respect to the structure and function
Q20: Which of the following voltage-activated sodium channels
Q22: The α-subunit of the voltage-activated potassium channel
Q23: Which of the following characteristics are similar
Q24: Which of the following characteristics are similar
Q25: What senses membrane potential in voltage-activated channels?
A)
Q26: m1 and m2 of KCS channels most
Unlock this Answer For Free Now!
View this answer and more for free by performing one of the following actions
Scan the QR code to install the App and get 2 free unlocks
Unlock quizzes for free by uploading documents