With regard to ion channel opening, the M1 ligand-binding domain of Cys-loop receptors functionally corresponds to which of the following regions of voltage-activated ion channels?

Question

Quizplus · Accepted Answer

The M1 ligand-binding domain of Cys-loop receptors corresponds to the S4 transmembrane domain of voltage-activated ion channels. The S4 domain is crucial for sensing changes in voltage across the membrane, which triggers the opening of these channels, similar to how ligand binding to the M1 domain induces conformational changes leading to channel opening in Cys-loop receptors.

With Regard to Ion Channel Opening, the M1 Ligand-Binding Domain