Peripheral tolerance is a mechanism that prevents the immune system from attacking the body's own tissues. It involves the induction of anergy in T cells, which occurs when there is T cell receptor (TcR) engagement with the MHC-peptide complex without the necessary costimulatory signals. This lack of costimulation leads to the T cell becoming unresponsive or anergic, thus preventing an autoimmune response.

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Peripheral Tolerance

Question 9

Multiple Choice

Peripheral tolerance

A) is caused by costimulation without TcR-MHC₊ peptide interaction.
B) is caused by TcR-MHC₊ peptide interaction without costimulation.
C) leads to anergy.
D) both leads to anergy and is caused by costimulation without TcR-MHC₊ peptide interaction.
E) both leads to anergy and is caused by TcR-MHC₊ peptide interaction without costimulation.

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