Autoimmune diseases involve both a failure of central tolerance (the process by which self-reactive T cells are eliminated in the thymus) and peripheral tolerance (the mechanisms that prevent activated T cells from attacking self tissues outside of the thymus), leading to tissue destruction as the immune system attacks the body's own cells.

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Autoimmune Diseases

Question 16

Multiple Choice

Autoimmune diseases

A) involve a failure of central tolerance.
B) involve a failure of peripheral tolerance.
C) lead to tissue destruction.
D) All of the answers are correct.
E) None of the answers are correct.

Correct Answer: