To Avoid Returning to the Lymph Nodes, Effector Cells

To avoid returning to the lymph nodes, effector cells

A) up-regulate chemokine receptors to allow them to home in to site of infection.
B) down-regulate L-selectin, so they do not enter the high-endothelial venules (HEVs) .
C) down-regulate chemokine receptors, so they do not enter the high-endothelial venules (HEVs) .
D) up-regulate chemokine receptors and downregulate L-selectin.
E) down-regulate both L-selectin and chemokine receptors.